Exploring Role of Methylergometrine in clinical practice : A comprehensive medical consensus

• Atul Munshi,  
• Milind Gaitonde,  
• MAYANK DHORE,*  
• Ninad Chaudhary,  
• Snehal Muchhala,  
• Bhavesh Kotak

Abstract

Postpartum haemorrhage (PPH) is a major cause of morbidity and mortality, with uterine atony accounting for 70-80% of all haemorrhages. According to the experts, the incidence of PPH ranges from 3% to 5%. The most common causes include uterine atony, laceration, accidental haemorrhage, and abnormal placentation. Factors that increase the risk of PPH include advanced age, assisted reproduction technology, and advanced age-associated co-morbidities. Even though guidelines recommend oxytocin as the first option, experts consider methylergometrine to be the ideal uterotonic in clinical practice in case of either normal vaginal or C-section delivery. The current consensus article aims to provide a collation of evidence-based literature and clinical insights from the experts on epidemiology, risk factors, and predictors of PPH. The article also provides a consensus on the role of methylergometrine (methylergonovine) in the management of PPH. Overall, methylergometrine alone or in combination with oxytocin is among the first-line drugs for the management of PPH with a favourable safety profile and cost-effectiveness.

Keywords

Postpartum haemorrhage ,uterine atony,accidental haemorrhage