LACTATE DEHYDROGENASE AS A BIOCHEMICAL MARKER FOR PREDICTION OF MATERNAL AND PERINATAL OUTCOMES IN HYPERTENSIVE DISORDERS IN PREGNANCY

• Dr. Neha kumari,*  
• Dr. Ripan Bala,  
• Dr. Sangeeta Pahwa

Abstract

ABSTRACT Introduction: Hypertensive disorder of pregnancy includes new onset hypertension in pregnancy that is gestational hypertension and already existing hypertension that is chronic hypertension and gestational hypertension sometimes worsened by preeclampsia. Preeclampsia can cause complications such as eclampsia, HELLP syndrome, renal failure, pulmonary edema, stroke, and left ventricular failure. Aim: we aim to assess the predictive role of Lactate Dehydrogenase value in Hypertensive disorders in pregnancy. Material and Methods: Antenatal women beyond 28 weeks of gestation visiting Sri Guru Ram Das Universty of Health and science, Amritsar were enrolled after informed consent. Patients were included from antenatal OPD as well as from those presenting in emergency. Serum levels of LDH were analyzed. Patients were followed up till delivery and 6 weeks post-partum. RESULTS: Mean serum lactate dehydrogenase (LDH) level in eclamptic women was 1495.000±859.1230, in severely preeclamptic women was 804.569±224.5519, mild preeclamptic women were 520.062±110.3944.The difference between preeclamptic-eclamptic women was statistically significant (p < 0> 800 IU/L, 600-800 IU/L compared to those who had < 600 IU/L LDH levels. Conclusion: Serum LDH levels higher in women of preeclamptic-eclamptic group. Higher LDH levels correlated with disease severity and associated with poor maternal outcomes like placental abruption, hemolysis elevated liver enzymes low platelet count (HELLP), pulmonary edema, and maternal death and also associated with fetal complications like intrauterine fetal death (IUFD), neonatal intensive care unit (NICU) admission.

Keywords

low birth weight, abruptio placenta, serum LDH, eclampsia, preeclampsia.