Randomized Comparative Study Between Ferric Carboxymaltose and Iron Sucrose for Correction of Anemia in Antenatal Women

• Sanchita Hegde,  
• Ashwini Mallikarjun Kollur,*  
• Mahalakshmi Someshwar Gaddi,  
• Sunita Patil

Abstract

Background: Anemia during pregnancy is a significant global health concern. This study aims to evaluate the efficacy and safety of Ferric Carboxymaltose (FCM) compared to Iron Sucrose (ISC) in treating mild to moderate iron deficiency anemia (IDA) in pregnant women. Methods: This randomized prospective control study involved antenatal women with mild to moderate anemia attending the clinic at Sri Dharmasthala Manjunatheshwara College of Medical Sciences and Hospital from December 2018 to November 2019. Participants were randomly divided into two groups: Group A (FCM) and Group B (ISC). Results: A total of 128 women were randomized, with 64 in each group. The mean increase in hemoglobin was significantly higher in the FCM group (1.34 g/dl) compared to the ISC group (0.98 g/dl) (p < 0.001). FCM required fewer administrations, improving patient compliance. Both treatments were well-tolerated, with minor local reactions observed. Conclusion: FCM offers a more effective, convenient, and well-tolerated treatment option for IDA in pregnancy compared to ISC.

Keywords

Ferric Carboxymaltose, Iron Sucrose, Pregnancy, Anemia, Randomized Controlled Trial