THYROID STATUS IN PREECLAMPTIC PATIENTS AND IN NORMAL PREGNANCY:- A CASE CONTROL STUDY

• Piyush Joshi,*  
• asha sharma,  
• Abhijit Basu

Abstract

ABSTRACT: AIM:- To compare thyroid status in patients of pre- eclampsia and normal pregnant women in third trimester of pregnancy. MATERIALS & METHODS:- This case control study was conducted from Dec. 2015 to June 2017 in Geetanjali Medical College & Hospital, Udaipur. It was performed on 50 preeclamptic women (case group) and 50 normal normotensive pregnant women (control group) in third trimester of pregnancy. RESULT: The difference in Mean T3 value amongst case group and control group was not statistically significant with p = 0.844. The difference in Mean T4 value amongst case group and control group was statistically significant with p = 0.011. The difference in Mean TSH amongst case group and control group was statistically significant with p= 0.00068. Prevalence of hypothyroidism in preeclamptic women was 44% as compared to 16% in control group and p value was 0.00225, which was statically significant. If the titers of TSH were above 4.04 μIU/ml, then there was 4 times higher risk of the development of preeclampsia. CONCLUSION: Present study suggested that primary hypo-functioning of the thyroid can accompany preeclampsia and possibly contribute to the pathogenesis. The decrease in thyroid hormones with concomitant increase in TSH titers has been found to be correlated with the severity of preeclampsia.

Keywords

Pregnancy, Preeclampsia, Thyroid hormones, Hypothyroidism