A COMPARATIVE STUDY OF IRON ISOMALTOSIDE VERSUS IRON SUCROSE IN TREATING ANEMIA IN POSTPARTUM

• PRAJAKTA BAJARANG BHOSLE,*  
• shailaja R Bidri,  
• Rajasri G Yaliwal

Abstract

BACKGROUND The most frequent hematological disorder identified during pregnancy is anemia. Anaemia during pregnancy is described by the World Health Organization as having a hemoglobin concentration of less than 11 gm% and a hemocrit of less than 33%. This study aimed to examine the safety, effectiveness, of intravenous iron isomaltoside vs intravenous iron sucrose in the treatment of postpartum anemia. METHODOLOGY This Randomised parallel group trial study will be done in the Department of Obstretrics and Gynaecology Shri B. M. Patil Medical College Hospital and Research Centre. All postpartum women between day 1 and day 10 of normal delivery or cesarean section with moderate anaemia ( Hb 7-11 gm/dl) admitted in labour room and wards and agreeing to give written and informed consent will be included in the study. Then subjects will be randomized in to two groups in 1:1, 108 subjects in each group Group 1- Received 1 gm of intravenous iron isomaltoside in a single dose. Group 2- Received 600mg of intravenous Iron sucrose divided in three doses of 200 mg, 200 mg and 200 mg on each day. Then the CBC and serum ferritin levels will be checked on the recruitment day followed by 21st day after therapy. RESULT Women in iron isomaltoside group achieve Hb rise of 1.4 gm as compared to in iron sucrose group, which was highly significant (P value <0.001) mean size of Hb was 2.086 mg for iron isomaltoside group and 1.766 gm for iron sucrose group, which was also significant. Serum ferritin, which is a marker of iron stores rise in both the groups. CONCLUSION Iron isomaltoside is an efficient alternative to Iron Sucrose in treating postpartum anemia. It has an added advantage of single dose regime and lower incidence of side effects.

Keywords

Iron isomaltoside, Iron sucrose, Postpartum anemia, Anemia, Anemia in puerperium.