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A demographic and clinico pathological study of HPV associated cofactors in the pathogenesis of cervical cancer

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Original Article

Author Details : Saswati Mukhopadhyay*

Volume : 6, Issue : 4, Year : 2019

Article Page : 472-479

https://doi.org/10.18231/j.ijogr.2019.103

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Abstract

Aims: Cervical carcinogenesis is a multi-step process associated with refractory infection by highrisk
human papillomavirus (HPV) types. Only a minority of HPV infected women develop cervical
intraepithelial neoplasia (CIN) or cervical cancer, indicating that HPV infection is not the sole risk factor
to induce cervical cancer. The present study aimed to identify the association of demographic and clinic
pathological factors in persistent high risk HPV infections of cervix and progression to cervical cancer in
East Indian women.
Materials and Methods: Study subjects comprised 71 women with histologically proven cervical cancer,
and 100 women with benign cervical lesions. The case group included HPV 16 +ve subjects with
malignancy. Among subjects with benign lesions, 43 were HPV 16 +ve (intermediate group) and 57
were HPV – ve (control group). Demographic factors like age at diagnosis, age at first childbirth, parity,
postmenopausal status, literacy, smoking and clinic pathological factors like type of cervical cancer and
grading were correlated with HPV infections and cervical cancer. HPV status and HPV Type was confirmed
by PCR based method, using specific primers.
Results: There was significant association between HPV +ve individuals (both cases and intermediates)
and increased parity, post menopause, increased age at diagnosis, decreased age at first childbirth, illiteracy
and smoking. All individuals of the case group were HPV +ve, type 16 and most had poorly differentiated
and stage III squamous cell carcinoma of the cervix.
Conclusion: Our study suggests that demographic factors should be taken into account when screening for
HPV infectivity and cervical cancer.

Keywords: Cancer cervix, Demographic factors.

How to cite : Mukhopadhyay S, A demographic and clinico pathological study of HPV associated cofactors in the pathogenesis of cervical cancer. Indian J Obstet Gynecol Res 2019;6(4):472-479

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