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Variant hook effect: A cause of false negative result in point of care testing

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Case Report

Author Details : Monu Singh, B Preethi*, Achla Batra, Pallavi

Volume : 7, Issue : 2, Year : 2020

Article Page : 263-266

https://doi.org/10.18231/j.ijogr.2020.056

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Abstract

Beta Human Chorionic Gonadotrophin (b hCG) assays are sandwich chromatographic immunoassays
which give a false negative results at high hCG concentrations and also in the presence of variants of
hCG like hyperglycosylated hCG and hCG core fragments. This is imperative in everyday clinical scenario
as it delays the diagnosis of pregnancy and its related complications. We have discussed two such cases
where in the first case the diagnosis of hydatidiform mole was delayed due hook effect whereas in the
second case the diagnosis of GTD was missed because of variant hook effect.

Keywords: Hcg – human chorionicganadotropin.

How to cite : Singh M, Preethi B , Batra A, Pallavi, Variant hook effect: A cause of false negative result in point of care testing. Indian J Obstet Gynecol Res 2020;7(2):263-266

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