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A clinical update on the molecular pathogenesis of gestational diabetes mellitus and its consequences

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Review Article

Author Details : Balaji Vijayam*, Taarika Balaji, Madhuri S Balaji, Seshiah Veerasamy, Vinothkumar Ganesan

Volume : 9, Issue : 2, Year : 2022

Article Page : 147-152

https://doi.org/10.18231/j.ijogr.2022.031

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Abstract

Gestational diabetes mellitus (GDM) is becoming more common all over the world, mainly to an increase in maternal obesity. There have been a number of approaches to screening for and diagnosing GDM described, however there is no consensus on which methods are the most effective. For the mother, developing fetus, and children born to mothers with GDM, GDM poses severe short and long-term health hazards. Macrosomia, shoulder dystocia, delivery trauma, and hypoglycemia in the immediate postpartum period are all short-term dangers for the fetus. Increased rates of childhood and adulthood obesity, as well as a higher cardio metabolic risk, are long-term hazards for offspring born to women with GDM. More investigations on the aetiology and underlying mechanisms of gestational diabetes and its complications on the long-term health of offspring are needed to offer a foundation for creating effective therapies during this important period with the goal of promoting lifelong health and well-being.
 

Keywords: Diabetes mellitus, Insulin resistance, Gestational diabetes mellitus, Macrosomia

How to cite : Vijayam B, Balaji T, Balaji M S, Veerasamy S, Ganesan V, A clinical update on the molecular pathogenesis of gestational diabetes mellitus and its consequences. Indian J Obstet Gynecol Res 2022;9(2):147-152

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