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Critical analysis of misoprostol versus mifepristone with misoprostol in medical termination of pregnancy

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Original Article

Author Details : Hanumant V Nipanal*, Swetha Doddiah, Soubhagya R Talawar

Volume : 10, Issue : 3, Year : 2023

Article Page : 266-271

https://doi.org/10.18231/j.ijogr.2023.055

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Abstract

Background: Termination of pregnancy by any method before the viable period is called abortion. Medical methods can avoid complications of surgical method of abortion which has many disadvantages like perforation of uterus, hemorrhage, sepsis and increased morbidity. The WHO has approved mifepristone and misoprostol combination for medical abortion.
Aims and Objectives: 1. To compare the efficacy of Misoprostol versus combination of mifepristone with Misoprostol. 2. To asses the side effects of Misoprostol and combinationion of Mifepristone and Misoprostol.
Materials and Methods: It is prospective observational study consisting of two groups with each 61 subjects of MTP patients. Group A (Misoprostol alone): Receive tablet misoprostol 600 microgram start placed per vaginally followed by 400 microgram misoprostol tablet placed per vaginally every 4 hourly up to maximum five doses. In case of first trimester cases 800 microgram tablet misoprostol placed per vaginally followed by 400 microgram misoprostol tablet placed per vaginally every 4 hourly up to maximum four doses. Group B (Mifepristone and Misoprostol): Receive tablet mifepristone 200mg orally on empty stomach. After 24 hours will receive tablet misoprostol as mentioned in group A.
Results: Misoprostol alone has success rate of 78.69% whereas combination with Mifepristone success was 93.44%. The mean Induction - abortion interval in misoprostol alone group was 11.803 hours and with mifepristone combination it was B5.623 hours.
Conclusion: Medical termination of pregnancy by sequential administration of mifepristone with misoprostol has less induction abortion interval compared to using misoprostol alone. This combination has more success rate and also has lesser side effects.
 

Keywords: Medical termination of pregnancy, Misoprostol, Mifepristone, Misoprostol versus mifepristone, MTP

How to cite : Nipanal H V, Doddiah S, Talawar S R, Critical analysis of misoprostol versus mifepristone with misoprostol in medical termination of pregnancy. Indian J Obstet Gynecol Res 2023;10(3):266-271

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