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A prospective study of sublingual misoprostol (PGE1) versus intracervical dinoprostone (PGE2) followed by sublingual misoprostol (PGE1) for induction of labour in singleton full term pregnancy

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Original Article

Author Details : Rakhee R. Sahu, Anjali Sonawane

Volume : 3, Issue : 4, Year : 2016

Article Page : 307-313

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Abstract

Prostaglandins E1 and E2 have been extensively used for cervical ripening and induction of labour. The objective of our study is to compare the efficacy of sublingual route of misoprostol along with intracervical Dinoprostone gel as induction method.
Methods: This is a randomized prospective interventional study conducted in 100 full term pregnant women.  Group1- 50 cases- Tablet Misoprostol 50 mcg sublingual followed by tablet Misoprostol 25 mcg sublingually 4 hourly, to maximum of 200 mcg.
Group  2 – 50 cases - PGE2 gel (0.5mg, 6 hourly  two gels) intracervical application followed by tablet Misoprostol 50 mcg sublingual followed by Tab. Misoprostol 25mcg sublingually 4 hourly, to maximum of 200 mcg.
Results: There was no significant difference between group 1 and 2 for demographic characteristics, gravidarum, Bishop’s score.
The mean duration of latent phase for Group 1 was significantly shorter (11hrs 40 min) than that in Group 2 (21hrs 36 min). There was no significant difference in mean duration of active phase of labour between the 2 groups.
In our study the mean  induction to delivery interval (IDI) for Group 1 was 15 hrs 16 min (6.33), whereas  the mean  induction to delivery interval for Group 2 was 25 hrs 3 min (7.43) which was statistically significant (P value <0.0001).
There was no significant difference in mode of delivery and fetal Apgar score between the 2 groups.
Conclusion: Misoprostol alone was more efficient than Dinoprostone followed by Misoprostol in terms of short Induction to Delivery interval.

Keywords: Induction of labour, Misoprostol, Dinoprostone

How to cite : Sahu R R, Sonawane A, A prospective study of sublingual misoprostol (PGE1) versus intracervical dinoprostone (PGE2) followed by sublingual misoprostol (PGE1) for induction of labour in singleton full term pregnancy. Indian J Obstet Gynecol Res 2016;3(4):307-313

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