Indian Journal of Obstetrics and Gynecology Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-2746
Online ISSN: 2394-2754
CODEN : IJOGCS
Indian Journal of Obstetrics and Gynecology Research (IJOGR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 4, Issue : 1, Year : 2017
Article Page : 6-9
Abstract
Background: Conventionally, carcinomas of the ovary have been thought to arise de novo from the ovarian surface. However recent studies have indicated that putative ‘precursor’ changes are present in the fimbrial ends of fallopian tubes.
Aims: The study was aimed to identify histological changes in the fimbrial ends of fallopian tubes across three sets of patients.
Settings and design: Histological sections from fimbrial ends of fallopian tubes from a total of 14 women who underwent prophylactic salpingo-oopherectomy for non-neoplastic diseases, twelve who were treated for non-serous ovarian carcinoma and nine consecutive cases of ovarian serous carcinoma cases over a three year period from a tertiary care hospital were studied.
Methods and Materials: Sections were stained with hematoxylin-eosin and p53 immunohistochemical staining.
Statistical analysis used: One-way ANOVA (Analysis of Variance).
Results: Histological changes in the fimbriae ranging from SCOUT to STIL and STIC and p53 signatures were found across all three populations but were multifocal and significantly higher in cases of ovarian serous carcinoma.
Conclusions: Our study identified statistically significant differences in histological changes and p53 immunostaining in the fimbrial end of fallopian tubes across three populations of patients.
Keywords: Ovarian serous carcinoma, Fallopian tube, Secretory Cell Outgrowths (SCOUTs), Serous Tubal Intermediate Lesions (STILs), Serous Tubal Intraepithelial Carcinoma (STIC), p53 signatures
How to cite : Jassar A, Patil D, TUBAL SCOUTs, STILs, STICs and p53 Signatures: Understanding the new language in ovarian serous carcinoma. Indian J Obstet Gynecol Res 2017;4(1):6-9
This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
