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A prospective trial to study the safety and effectiveness of oral RU-486 (mifepristone) and Prostaglandin analogue (misoprostol) in missed abortion

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Original Article

Author Details : Pranabika Mahanta, Phatik Chandra Kalita, Anuradha Hazarika Medhi

Volume : 4, Issue : 2, Year : 2017

Article Page : 151-154

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Abstract

Aim: To evaluate the effectiveness of oral Ru-486 (mifepristone) and Prostanglandin analogue (misoprostol) in facilating spontaneous abortions in pregnant women with missed abortion and also to study its safety and side-effects associated with these drugs.
Materials and Methods: This study was undertaken in the Department of Obstetrics & Gynaecology, Jorhat Medical College & Hospital, Jorhat Assam from August 2012 to June 2013. It was a prospective study. In this study 60 patients attending gynaecology OPD with a diagnosis of missed abortion were included. The diagnosis is confirmed with ultrasonography. Patient with diagnosis of missed abortions were first counselled for medical abortion. They were also counselled for the need of surgical intervention if this fails. Written consent is taken. Heamoglobin estimation, ABO grouping and Rh typing, platelet count Bleeding time clotting time, s.creatinine, liver function test were the minimum investigations done before prescribing the drugs. Tab mifepristone 200mg is advised to take on day 1, followed by tab Prostanglandin analogue 800microgam on day 3 after 48 hrs. Patient’s data were entered in a pretested questionnaire. Patients are asked to attend OPD after one week. Again they are interviewed with the same questionnaire to find of any side effect or complications. On day 10 ultrasonography was done to confirm complete abortion of the product of conceptus. Data were analysed with statistical tests.
Results: Data were analysed using the SPSS for Windows Statistical Package.
Conclusion: The results of the present study suggest that the use of mifegest and misoprost orally is safe and effective to induce expulsion of the products of conception in cases with diagnosis of missed abortion.

Keywords: Missed abortion, l Ru-486, Mifepristone, Prostanglandin analogue, Misoprostol

How to cite : Mahanta P, Kalita P C, Medhi A H, A prospective trial to study the safety and effectiveness of oral RU-486 (mifepristone) and Prostaglandin analogue (misoprostol) in missed abortion. Indian J Obstet Gynecol Res 2017;4(2):151-154

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