Indian Journal of Obstetrics and Gynecology Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-2746
Online ISSN: 2394-2754
CODEN : IJOGCS
Indian Journal of Obstetrics and Gynecology Research (IJOGR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 4, Issue : 2, Year : 2017
Article Page : 151-154
Abstract
Aim: To evaluate the effectiveness of oral Ru-486 (mifepristone) and Prostanglandin analogue (misoprostol) in facilating spontaneous abortions in pregnant women with missed abortion and also to study its safety and side-effects associated with these drugs.
Materials and Methods: This study was undertaken in the Department of Obstetrics & Gynaecology, Jorhat Medical College & Hospital, Jorhat Assam from August 2012 to June 2013. It was a prospective study. In this study 60 patients attending gynaecology OPD with a diagnosis of missed abortion were included. The diagnosis is confirmed with ultrasonography. Patient with diagnosis of missed abortions were first counselled for medical abortion. They were also counselled for the need of surgical intervention if this fails. Written consent is taken. Heamoglobin estimation, ABO grouping and Rh typing, platelet count Bleeding time clotting time, s.creatinine, liver function test were the minimum investigations done before prescribing the drugs. Tab mifepristone 200mg is advised to take on day 1, followed by tab Prostanglandin analogue 800microgam on day 3 after 48 hrs. Patient’s data were entered in a pretested questionnaire. Patients are asked to attend OPD after one week. Again they are interviewed with the same questionnaire to find of any side effect or complications. On day 10 ultrasonography was done to confirm complete abortion of the product of conceptus. Data were analysed with statistical tests.
Results: Data were analysed using the SPSS for Windows Statistical Package.
Conclusion: The results of the present study suggest that the use of mifegest and misoprost orally is safe and effective to induce expulsion of the products of conception in cases with diagnosis of missed abortion.
Keywords: Missed abortion, l Ru-486, Mifepristone, Prostanglandin analogue, Misoprostol
How to cite : Mahanta P, Kalita P C, Medhi A H, A prospective trial to study the safety and effectiveness of oral RU-486 (mifepristone) and Prostaglandin analogue (misoprostol) in missed abortion. Indian J Obstet Gynecol Res 2017;4(2):151-154
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