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IS TESTING OF MENSTRUAL BLOOD JUSTIFIABLE FOR DIAGNOSIS OF ENDOMETRIAL TUBERCULOSIS AMONG INFERTILE WOMEN?

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Author Details : Anushree. D. Patil, Sushil K Shinde, Geetanjali M. Sachdeva, Achhelal R. Pasi, Shanta M. Chitlange,

Volume : 2, Issue : 2, Year : 2015

Article Page : 103-107

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Abstract

Introduction: Diagnosis of endometrial tuberculosis is often carried out by using commercially available molecular diagnostic tests on endometrial biopsy samples and menstrual blood samples of infertile women in many infertility clinics.

Aim: To determine whether menstrual blood is a good alternative sample for diagnosis of endometrial tuberculosis.

Methods: Women (n=123) presenting with infertility were investigated for endometrial tuberculosis by testing menstrual blood samples as well as endometrial aspirates with GEN-PROBE AMPLIFIED Mycobacterium Tuberculosis Direct (MTD) test which is a Nucleic Acid Amplification Test (NAAT) and VersaTREK culture. Results of the two tests for detection of M. Tuberculosis were compared in menstrual blood and endometrial aspirate samples.

Results: Out of 123 menstrual blood samples tested M. tuberculosis was detected by culture in only 0.8 per cent of women. Mycobacterium other than Tuberculosis (MOTT) was detected in 2.43 per cent samples of menstrual blood on culture reports and was identified to be Mycobacterium inter medium.

Conclusion: Menstrual blood was not found as a good alternative sample for diagnosis of endometrial tuberculosis. Results of MTD tests on menstrual blood sample for diagnosis and management of endometrial tuberculosis (as is widely used in infertility clinics) should be interpreted with caution. Pathological significance of Mycobacterium inter medium in female infertility, though a possible contaminant, needs further research.

Keywords: Endometrial tuberculosis, Infertility, Menstrual blood samples.

How to cite : Patil A D, Shinde S K, Sachdeva G M, Pasi A R, Chitlange S M, , IS TESTING OF MENSTRUAL BLOOD JUSTIFIABLE FOR DIAGNOSIS OF ENDOMETRIAL TUBERCULOSIS AMONG INFERTILE WOMEN?. Indian J Obstet Gynecol Res 2015;2(2):103-107

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