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Comparison of effectiveness of ormeloxifene with norethisterone in perimenopausal DUB treatment

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Original Article

Author Details : Surabhi HD, Chandra Mouli A*

Volume : 6, Issue : 2, Year : 2019

Article Page : 137-140

https://doi.org/10.18231/j.ijogr.2019.032

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Abstract

Introduction: Dysfunctional Uterine Bleeding, is Abnormal uterine bleeding in the absence of organic, systemic, iatrogenic cause.¹ Norethisterone acetate is commoly used progesterone derivative for management.² Ormeloxifene, a selective estrogen receptor modulator is an another alternate treatment for DUB.³ Study was conducted at MVJ Medical College Bangalore. 
Objective: to compare treatment efficacy and usefulnes of Ormeloxifene and oral progesterone in DUB treatment.
Materials and Methods: Total of 60 perimenopausal women with DUB were enrolled in our prospective study. They were randomly assigned to group A and group B.
Group A: 30 women with DUB were treated with 60mg Ormeloxifene two times a week for 3 months, 60mg weekly once for next 3 months.
Group B: Norethisterone 5 mg two times a day for 21 days for 6 cycles.
Results: In our study even though Norethistrone group showed significant reduction in blood loss and also increase in haemoglobin level, these results were significantly less when compared with Ormeloxifene group.
In addition Ormeloxifene group showed significant reduction in endometrial thickness, which was not significantly reduced in Norethisterone group. As a result of significant reduction of endometrial thickness among the women treated with Ormeloxifene.
Conclusion: In the study Ormeloxifene was found to be effective than Norethisterone in reducing blood loss, improving Haemoglobin level and reducing endometrial thickness for treating DUB patients. Also compliance of the patients was good because drug was well tolerated, convenient dosage schedule for treatment of DUB.

Keywords: Ormeloxifene, Norethisterone, Haemoglobin, Endometrial thickness, PBAC.

How to cite : Surabhi Hd, Chandra Mouli A, Comparison of effectiveness of ormeloxifene with norethisterone in perimenopausal DUB treatment. Indian J Obstet Gynecol Res 2019;6(2):137-140

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