Indian Journal of Obstetrics and Gynecology Research
Official Publication of Innovative Education and Scientific Research Foundation
Official Publication of Innovative Education and Scientific Research Foundation
Print ISSN: 2394-2746
Online ISSN: 2394-2754
CODEN : IJOGCS
Indian Journal of Obstetrics and Gynecology Research (IJOGR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...Original Article
Author Details :
Volume : 6, Issue : 2, Year : 2019
Article Page : 202-207
https://doi.org/10.18231/j.ijogr.2019.046
Abstract
Aims and Objectives: To compare the effect of mifepristone and ormeloxifen on symptomatology, size and vascularity of fibroid and also to compare the compliance and side effects of both these drugs.
Materials and Methods: This study was conducted in the department of obstetrics and gynecology at Swaroop Rani Nehru hospital, Allahabad and Kamla Nehru memorial hospital, Allahabad over a period of one year between 2016-2017 in 90 fibroid patients who gave consent for the study. Depending on their choice they were randomly divided into 2 groups. Group A included 44 fibroid patients who were given mifepristone and Group B included 46 fibroid patients were given ormeloxifen. Assessment of heavy menstrual bleeding by pictorial blood loss assessment chart, dysmenorrhea and dyspareunia by visual analogue scale, estimation of hemoglobin and repeat imaging to assess size, number, endometrial thickness, Doppler velocimetry of fibroid was done and all variables were compared in relation to pretreatment and post-treatment parameters by using chi square test.
Results: 97.7% patients in group A and 95.6% patients in group B were compliant towards treatment. A significant reduction in HMB (group A-51.16% to 18.6% $ group B-45.45% to 20.45%),mean pbac score(group A-246.6 to 65.2;p<0>
Conclusion: Mifepristone and ormeloxifen were equally effective for symptomatic relief in fibroid patients. Myoma size was significantly reduced by mifepristone only, with notable endometrial hyperplasia whereas ormeloxifen causes significant reduction in endometrial thickness. No major side effects observed with any of them.
Keywords: Mifepristone, Ormeloxifen, Leiomyoma, SERM, PBAC score.
How to cite : Singh M, Chourasia A, Singh S, Sachan N, Comparison of ormeloxifen and mifepristone in management of leiomyoma uterus. Indian J Obstet Gynecol Res 2019;6(2):202-207
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