Association of NLRP3 inflammasome and Fretibacterium species human oral taxon 360 in patients with periodontitis and gynaecological disorders: A correlative study

• Author Details:   
• Madhumathi Devaraj
• Muthukumar Santhanakrishnan ^*
• Sri Vidhya Marimuthu

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Background: The most prevalent endocrine diseases with multifactorial etiology are Polycystic Ovary Syndrome (PCOS) and Gestational Diabetes Mellitus (GDM). Chronic Periodontitis (CP) is an immunoinflammatory disease, studies suggest that CP is linked to PCOS and GDM. This study evaluated Fretibacterium HOT 360 and NLRP3 inflammasome levels in individuals with periodontitis and gynaecological diseases, particularly PCOS and GDM.

Materials and Methods:  Totally 90 subjects were screened and they were categorised into Group 1 (N=45: Patients with gynaecological disorders and without periodontitis) and Group 2 (N=45: Patients with gynaecological disorders + Periodontitis). Saliva samples were collected to assess the levels of NLRP3 inflammasome and Fretibacterium HOT 360 using an ELISA and conventional PCR respectively. Periodontal parameters (Plaque score, PD, CAL, PISA) were evaluated for all the patients.

Results: The mean concentration of NLRP3 inflammasome and Fretibacterium HOT 360 was significantly higher in group 2 (Patients with gynaecological disorders and Periodontitis) than group 1 (Patients with gynaecological disorders and without periodontitis) at p< 0>Fretibacterium HOT 360 were positively correlated with all the periodontal parameters (Plaque score, PD, CAL, PISA) in both the groups with the higher value in group 2.

Conclusion: There is an association between chronic periodontitis and gynaecological disorders (PCOD and GDM) as demonstrated by significant levels of NLRP3 inflammasome and Fretibacterium HOT 360 levels in patients with periodontitis and gynaecological disorders.

Keywords: Chronic periodontitis, Polycystic ovary syndrome, Insulin resistance, NLRP3 inflammasome, Fretibacterium.