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A comparative study of the accuracy of the spot Protein-Creatinine Ratio (PCR) vs 24 hours urine collection for detection of proteinuria in pre- eclamptic patients and its effect maternal and fetal outcomes

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Original Article

Author Details : Hemant Deshpade, C S Madkar*, Gurkiran Kaur, Swarna Gupta

Volume : 7, Issue : 1, Year : 2020

Article Page : 16-22

https://doi.org/10.18231/j.ijogr.2020.004

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Abstract

Introduction: Proteinuria is a major component of preeclampsia. Urine protein measurement after 24-hour
urine collection is the traditional standard method for the detection of proteinuria. It is time-consuming.
As an alternative, spot sampling for a urine protein to creatinine ratio (PCR) ratio has been investigated.
Aim & Objectives: To determine the accuracy of the spot protein- creatinine ratio in comparison with 24
hours urine collection for detection of proteinuria in pre- eclamptic patients.
Materials and Methods: A hospital based prospective study was conducted with 120 patients to assess
the quantification of proteinuria in preeclamptic patient and comparing the two methods i.e. 24-hr urine
protein levels and random protein creatinine ratio conducted at tertiary care centre.
Results: There was a good positive statistical correlation between 24-hour total urinary protein level and
spot protein: creatinine ratio with a correlation coefficient (r) of 0.769.Conclusion: Random and spot urine
protein creatinine ratio can predict with high accuracy the amount of 24- hour urine protein excretion. The
urine PCR is reliable, relatively faster and accurate for proteinuria and can correlate well with 24-hour
urinary protein excretion which is gold standard.

Keywords: Preeclampsia,Proteinuria, 24-hour urine collection, Spot urine PCR (protein to creatinine ratio)

How to cite : Deshpade H, Madkar C S, Kaur G, Gupta S, A comparative study of the accuracy of the spot Protein-Creatinine Ratio (PCR) vs 24 hours urine collection for detection of proteinuria in pre- eclamptic patients and its effect maternal and fetal outcomes. Indian J Obstet Gynecol Res 2020;7(1):16-22

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