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Hypo- vitaminosis D and its role in PCOS: A prospective observational study at Tertiary care Centre in North Indian population
Authors: Shalini Mishra, Neelam Swaroop, namrata sinha, Anima prasad, Annu mallik
DOI: 10.18231/j.ijogr.10428.1760521852
Keywords: KEYWORD: PCOS, Hyper-androgenism, BMI, DHEAS, Vitamin D , Fasting Insulin
Abstract: Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, characterized by oligo-menorrhea, hyper-androgenism, and metabolic disturbances. Vitamin D deficiency is common in PCOS patients and may exacerbate symptoms. This study aims to investigate the relationship between body mass index (BMI) and vitamin D levels in PCOS patients in a North Indian population. Methods: A prospective observational study was conducted at T.S. Mishra Medical College and Hospital from November 2023 to November 2024. A total of 156 patients aged 18-45 years with PCOS were enrolled based on modified Rotterdam criteria. Blood samples were analyzed for metabolic parameters, including serum vitamin D levels, and BMI was calculated. Statistical analysis was performed using SPSS 25.0. Results: The mean age of participants was 23.3 ± 1.4 years, with a mean BMI of 26.72 ± 1.6 kg/m2. Vitamin D deficiency (<20>30 ng/ml). No significant association was found between BMI categories and vitamin D levels (p=0.06719). However, significant differences were noted in metabolic parameters, with higher fasting insulin, DHEAS, and testosterone levels in vitamin D deficient patients (p<0.05). Conclusion: This study highlights a high prevalence of vitamin D deficiency among PCOS patients, with significant correlations between vitamin D levels and metabolic parameters, but not with BMI. These findings suggest the need for vitamin D assessment and potential supplementation in managing PCOS, particularly in the Indian population. KEYWORD: PCOS, Hyper-androgenism, BMI, DHEAS, Vitamin D , Fasting Insulin